You can’t do this, but what you can do is apply the drop-shadow to a pseudo-element that is the same size and uses a multiply blend mode.
.above {
position: absolute;
background: green;
width: 100px;
height: 100px;
}
.above::before {
box-shadow: 3pt 3pt 0 0 dodgerblue;
mix-blend-mode: multiply;
content: "";
position: absolute;
top: 0;
right: 0;
left: 0;
bottom: 0;
}
.below {
position: absolute;
top: 50px;
left: 50px;
width: 100px;
height: 100px;
background: red;
}
<div class="below">
</div>
<div class="above">
</div>
found here: https://stackoverflow.com/questions/52838406/apply-blend-mode-to-drop-shadow-only