Be careful to do this to make data searchable. Out of the box WPAlchemy uses WPALCHEMY_MODE_ARRAY which is not very useful for meta searches!

$custom_metabox = new WPAlchemy_MetaBox(array
(
    'id' => '_custom_meta',
    'title' => 'My Custom Meta',
    'template' => TEMPLATEPATH . '/custom/meta.php',
    'mode' => WPALCHEMY_MODE_EXTRACT,
    'prefix' => '_my_'
));

If you forget, use this:

    if ( ! function_exists( 'msd_convert_storage' ) ) :
            function msd_convert_storage($key,$prefix,$posttype) {
                    $args = array(
                        'numberposts'     => -1,
                        'post_type'       => $posttype,
                    );
                    $items = get_posts($args);
                    foreach($items AS $item){
                            $the_meta = get_post_meta($item->ID,$key);
                            $fields = array();
                            foreach($the_meta[0] AS $meta_key => $meta_value){
                                    $meta_key = $prefix.$meta_key;
                                    update_post_meta($item->ID, $meta_key, $meta_value);
                                    $fields[] = $meta_key;
                            }
                            update_post_meta($item->ID,$key.'_fields',$fields);
                            delete_post_meta($item->ID,$key);
                    }
            }
    endif;